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Potent antimalarial activity of the alkaloid nitidine, isolated from a Kenyan herbal remedy
D M Gakunju1, E K Mberu, S F Dossaji
1Ministry of Health, Nairobi, Kenya.
Antimicrobial Agents and Chemotherapy
|December 1, 1995
Abstract:
Bioassay-guided fractionation of extracts of Toddalia asiatica, a plant used by the Pokot tribe of Kenya to treat fevers, has yielded the alkaloid nitidine as the major antimalarial component. Fractions containing nitidine have in vitro 50% inhibitory concentrations against Plasmodium falciparum in the range of 9 to 108 ng/ml for a range of chloroquine-susceptible and -resistant strains. The results show a lack of cross-resistance between chloroquine and nitidine.