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Thalidomide inhibits lipoarabinomannan-induced upregulation of human immunodeficiency virus expression
P K Peterson1, G Gekker, M Bornemann
1Department of Medicine, Hennepin County Medical Center, Minneapolis, MN 55415, USA.
Antimicrobial Agents and Chemotherapy
|December 1, 1995
Abstract:
Mycobacterium tuberculosis accelerates the progression of human immunodeficiency virus type 1 (HIV-1) infection. The results of this study, which show that thalidomide inhibits the upregulation of HIV-1 expression in U1 cells stimulated with mycobacterial lipoarabinomannans, support the rationale behind conducting controlled trials of this immunodeficiency agent with patients dually infected with HIV-1 and M. tuberculosis.