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[Basic values of blood coagulation parameters in pigs (Sus scrofa domesticus)]
N Hahn1, S Popov-Cenic, A Dorer
1Experimentell-chirurgische Abteilung, Medizinischen Fakultät Bonn.
Berliner Und Munchener Tierarztliche Wochenschrift
|January 1, 1996
Summary
This study investigated blood plasma coagulation in healthy pigs, measuring 26 parameters to establish baseline values. Results indicate distinct differences in fibrinogenesis and fibrinolysis compared to humans.
Area of Science:
- Veterinary Hematology
- Comparative Coagulation Physiology
Background:
- Establishing baseline coagulation parameters in pigs is crucial for accurate interpretation of hemostasis.
- Understanding species-specific differences in coagulation is vital for preclinical research and veterinary medicine.
Purpose of the Study:
- To comprehensively investigate and define 26 blood plasma coagulation parameters in clinically healthy pigs.
- To establish reference values for coagulation tests in pigs for accurate diagnostic and research applications.
- To compare pig coagulation profiles with human values, highlighting species-specific variations.
Main Methods:
- Blood plasma from 23 healthy pigs (2-4 months old, 13-42 kg) was analyzed under ketamine-pentobarbital anesthesia.
- A panel of 26 coagulation parameters was measured, including platelet count, thrombelastogram, resonance-thrombogram, prothrombin time, activated partial thromboplastin time, thrombin time, reptilase time, coagulation factors (I, II, V, VII, VIII, X), antithrombin III, plasminogen, and inhibitors (alpha 1-antitrypsin, alpha 2-antiplasmin, alpha 2-macroglobulin).
- Fibrinolysis markers such as fibrin degradation products (D and E) and euglobulin lysis time were assessed. Reference values were determined against a pig plasma pool.
Main Results:
- A comprehensive set of 26 coagulation and fibrinolysis parameters was quantified in healthy pigs.
- Reference ranges were established using a pig plasma pool, with noted limitations for human plasma pool comparisons above 100%.
- Significant modifications in fibrinogenesis and fibrinolysis were observed in pigs when compared to human coagulation profiles.
Conclusions:
- The study provides essential baseline coagulation data for healthy pigs.
- Pig coagulation differs significantly from human physiology, particularly in fibrinogenesis and fibrinolysis.
- These findings are critical for the accurate use of pigs in preclinical hemostasis research and for veterinary diagnostics.