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Synthesis and biological evaluation of 7-azaanalogues of ipsapirone
W Malinka1, M Sielklucka-Dziuba, G Rajtar
1Department of Chemistry of Drugs, Wroclaw University of Medicine, Poland.
Abstract:
The synthesis and preliminary pharmacological evaluation of 4,6-dimethyl-7-azaipsapirone (5c) and related compounds bearing the r-(phenyl, pyridyl, pyrimidinyl)-1-piperazinyl moiety linked through a butyl or ethoxyethyl chain with the isothiazolo[5,4-b]pyridine system, are described.