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Updated: Jul 27, 2026
11:28
Dissecting Host-virus Interaction in Lytic Replication of a Model Herpesvirus
Published on: October 7, 2011
Molecular interactions between retroviruses and herpesviruses
1Department of Veterinary Microbiology, Faculty of Agriculture, University of Tokyo, Japan.
The Journal of Veterinary Medical Science
|October 1, 1995
Summary
Herpesviruses commonly activate retroviral gene expression, despite diverse mechanisms. This review explores molecular interactions in human, avian, and feline systems to explain this common activation theme.
Area of Science:
- Virology
- Molecular Biology
- Immunology
Background:
- Herpesviruses are known to stimulate gene expression in various human and animal retroviruses.
- This activation is a recurring phenomenon across different species and viral families.
- Understanding the molecular basis for this interaction is crucial for virology research.
Purpose of the Study:
- To investigate the common theme of herpesvirus-induced retroviral gene expression.
- To explore the molecular interactions underlying this phenomenon.
- To compare diverse retroviral systems activated by herpesviruses.
Main Methods:
- Comparative analysis of molecular interactions.
- Review of three key examples: human immunodeficiency virus/human herpesviruses, avian retroviruses/Marek's disease virus, and feline immunodeficiency virus/feline herpesvirus type I.
Main Results:
- Herpesviruses consistently activate retroviral gene expression through various molecular pathways.
- Despite mechanistic differences, a common theme of activation persists.
- Specific molecular interactions vary but lead to a similar outcome of enhanced retroviral activity.
Conclusions:
- Herpesvirus-retrovirus interactions represent a significant area in viral pathogenesis.
- Comparative molecular studies reveal conserved and divergent mechanisms of activation.
- Further research into these interactions could offer insights into viral co-infections and therapeutic strategies.
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