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Cloning and embryonic expression of Xenopus laevis GAP-43 (XGAP-43)
D H Shain1, D T Haile, T A Verrastro
1Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins 80523, USA.
Brain Research
|October 30, 1995
Abstract:
Xenopus laevis GAP-43 (XGAP-43) is highly related to other vertebrate GAP-43 proteins in its N-terminal region which contains a membrane-targeting sequence, serine phosphorylation site, and calmodulin binding domain. Unlike other species examined, however, there appear to be two GAP-43-class genes in X. laevis which resulted from the genome duplication in Xenopus approximately 30 million years ago. During embryogenesis, XGAP-43 is expressed in a complex spatiotemporal pattern that is consistent with its putative role in neuronal growth and development.