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Transplatin blocks voltage-dependent calcium current in isolated cochlear outer hair cells but is not ototoxic in
T Saito1, T Yamamoto, Z J Zhang
1Department of Otolaryngology, Fukai Medical School, Japan.
Brain Research
|October 30, 1995
Abstract:
The effects of cisplatin (cis-DDP) and transplatin (trans-DDP) on the voltage-dependent calcium current (ICa) of outer hair cells isolated from the guinea pig cochlea were compared using the whole-cell patch-clamp technique. Both cis-DDP and trans-DDP blocked ICa in a concentration-dependent manner. Trans-DDP did not show ototoxicity or nephrotoxicity in vivo. From these results, it was suggested that the effect of cis-DDP on ICa does not directly lead to cell death.