Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Developmental effects of dioxins

L S Birnbaum1

  • 1Health Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, NC 27711, USA.

Environmental Health Perspectives
|October 1, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Polychlorinated biphenyls, polychlorinated dibenzo-p-dioxins, polychlorinated dibenzofurans, pesticides, and diabetes in the Anniston Community Health Survey follow-up (ACHS II): single exposure and mixture analysis approaches.

The Science of the total environment·2023
Same author

An assessment of dioxin exposure across gestation and lactation using a PBPK model and new data from Seveso.

Environment international·2016
Same author

5th International PCB Workshop--summary and implications.

Environment international·2010
Same author

Effect of age on the in vitro percutaneous absorption of phenols in mice.

Toxicology in vitro : an international journal published in association with BIBRA·2010
Same author

Relative potency based on hepatic enzyme induction predicts immunosuppressive effects of a mixture of PCDDS/PCDFS and PCBS.

Toxicology and applied pharmacology·2008
Same author

Impact of repeated exposure on the toxicokinetics of BDE 47 in mice.

Toxicological sciences : an official journal of the Society of Toxicology·2005
Same journal

A New Start.

Environmental health perspectives·2026
Same journal

Time-Varying Exposure to Element Mixtures and Children's Cognition at 5 Years of Age: Findings from the New Hampshire Birth Cohort Study.

Environmental health perspectives·2026
Same journal

Effect of Household Air Pollution on the Gut Microbiome and Virome of Adult Women Living in Uganda.

Environmental health perspectives·2026
Same journal

Comparison of Temperature-Mortality Associations across the Middle East Using Different Exposure Estimation Approaches.

Environmental health perspectives·2026
Same journal

Workflow for Statistical Analysis of Environmental Mixtures.

Environmental health perspectives·2026
Same journal

Effects of Extreme Heat Exposure on Heatstroke and Liver Injury in Mice: The Role of PPARα.

Environmental health perspectives·2026
See all related articles

Dioxins cause potent developmental toxicity, including delayed functional deficits and subtle structural issues not apparent at birth. These effects, seen in animals and humans, highlight dioxins as complex endocrine disruptors affecting multiple pathways.

Area of Science:

  • Environmental Toxicology
  • Developmental Biology
  • Endocrinology

Background:

  • Dioxins are known for potent developmental toxicity across species.
  • Recent research reveals dioxins induce delayed functional and subtle structural developmental defects.
  • These effects are observed in both sexes and are not always detectable at birth.

Purpose of the Study:

  • To investigate the complex developmental toxicity of dioxins.
  • To explore the non-endocrine specific mechanisms of dioxin-induced developmental defects.
  • To understand dioxins as potent growth dysregulators impacting multiple biological pathways.

Main Methods:

  • Review of recent studies on dioxin developmental toxicity.
  • Analysis of structural and functional deficits in animal models and human populations.

Related Experiment Videos

  • Examination of endocrine pathway interactions, including estrogenic and antiestrogenic effects.

    • Main Results:

    • Dioxins induce delayed functional developmental defects and subtle structural deficits.
    • Effects are observed in multiple species and sexes, with some manifesting postnatally.
    • Prenatal exposure in humans to dioxin-like compounds has been linked to certain developmental defects.
    • Dioxin's effects are not attributable to a single endocrine system modulation.

    Conclusions:

    • Dioxins are potent growth dysregulators with complex developmental toxicity.
    • Their effects involve multiple biological pathways, not solely endocrine disruption.
    • Understanding dioxins as multi-pathway disruptors is key to addressing their developmental risks.