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Polyol pools in Aspergillus niger

C F Witteveen1, J Visser

  • 1Section Molecular Genetics of Industrial Microorganisms, Wageningen Agricultural University, The Netherlands.

FEMS Microbiology Letters
|December 1, 1995
PubMed
Summary
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Aspergillus niger accumulates glycerol for osmotic adjustment and mannitol in spores. Polyols are excreted and reabsorbed, with glycerol kinase mutants showing altered excretion levels.

Area of Science:

  • Microbiology
  • Biochemistry
  • Mycology

Background:

  • Polyols are crucial for osmotic adjustment in fungi.
  • Aspergillus niger utilizes various polyols throughout its life cycle.
  • Understanding polyol metabolism is key to fungal physiology.

Purpose of the Study:

  • To investigate polyol accumulation and excretion in Aspergillus niger.
  • To determine the role of different polyols during growth and germination.
  • To explore the physiological significance of polyol excretion.

Main Methods:

  • Culturing Aspergillus niger under diverse conditions.
  • Analyzing polyol content at different life cycle stages.
  • Utilizing a glycerol kinase mutant for comparative studies.

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Main Results:

  • Glycerol is the primary osmotic solute in hyphae.
  • Mannitol is abundant in conidiospores and metabolized during germination.
  • Polyols are excreted and reabsorbed; glycerol kinase mutants exhibit higher excretion.

Conclusions:

  • Polyol excretion may regulate intracellular polyol pools.
  • Fungal polyol dynamics are complex, involving synthesis, excretion, and reuptake.
  • Glycerol metabolism is essential for managing intracellular polyol levels in Aspergillus niger.