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Related Experiment Videos

Growth hormone does not prevent corticosteroid-induced changes in rat diaphragm structure and function

B J Petrof1, S B Gottfried, J Eby

  • 1Royal Victoria Hospital, Meakins-Christie Laboratories, McGill University, Montreal, Quebec, Canada.

Journal of Applied Physiology (Bethesda, Md. : 1985)
|November 1, 1995
PubMed
Summary

Growth hormone (GH) did not prevent corticosteroid-induced diaphragm atrophy in rats. This study found that GH did not reverse the negative effects of triamcinolone on diaphragm structure and function.

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Area of Science:

  • Physiology
  • Endocrinology
  • Muscle Biology

Background:

  • Corticosteroids, like triamcinolone (TR), can induce muscle atrophy.
  • Diaphragm dysfunction is a concern with corticosteroid therapy.
  • Growth hormone (GH) is an anabolic agent with potential therapeutic benefits.

Purpose of the Study:

  • To investigate if growth hormone (GH) administration can prevent diaphragm structural and functional abnormalities induced by short-term triamcinolone (TR) treatment.
  • To assess the impact of TR and co-administered GH on diaphragm weight, fiber cross-sectional area, and contractile properties.

Main Methods:

  • Male rats were divided into three groups: control (CTL), triamcinolone (TR), and triamcinolone plus growth hormone (TR-GH).
  • Animals received daily intramuscular injections for 10 days.

Related Experiment Videos

  • Diaphragm weight, fiber type proportions, fiber cross-sectional area, force-frequency relationship, in vitro fatigue resistance, and maximal specific force were analyzed.

    • Main Results:

    • Triamcinolone (TR) administration significantly reduced diaphragm weight and caused atrophy in type IIx/b fibers.
    • Growth hormone (GH) did not reverse the TR-induced type IIx/b fiber atrophy.
    • Both TR and TR-GH groups showed a left-ward shift in the force-frequency relationship and enhanced fatigue resistance, with no change in maximal specific force.

    Conclusions:

    • Growth hormone (GH) does not prevent corticosteroid-induced diaphragm abnormalities under the conditions of this study.
    • Reduced nutritional intake associated with triamcinolone administration may contribute to the observed effects.
    • Further research is needed to explore potential interventions for corticosteroid-induced muscle atrophy.