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MITOMAP: a human mitochondrial genome database

A M Kogelnik¹, M T Lott, M D Brown

¹Department of Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA.

Nucleic Acids Research

|January 1, 1996

Summary

We created MITOMAP, a database for human mitochondrial DNA (mtDNA). It integrates data on mtDNA structure, mutations, and variations, serving as a model for genomic databases.

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Area of Science:

Genomics
Bioinformatics
Molecular Biology

Background:

The human mitochondrial genome (mtDNA) was the first human genome component to be fully sequenced.
Integrating diverse biological data is crucial as genomic sequencing expands.

Purpose of the Study:

To develop a comprehensive database, MITOMAP, for human mitochondrial DNA (mtDNA).
To establish a unified system for organizing information related to mtDNA.

Main Methods:

Utilizing the complete human mtDNA sequence as a central organizing principle.
Integrating data on mitochondrial genome structure, function, and variations.

Main Results:

MITOMAP consolidates information on mtDNA structure and function.
The database includes data on pathogenic mutations, clinical characteristics, and population variations.
It also incorporates information on gene-gene interactions within the mitochondrial system.

Conclusions:

MITOMAP serves as a valuable reference for mitochondrial biologists.
The database design provides a model for future genomic information systems.
This approach facilitates the integration of complex genomic data.

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