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Progress with the PRINTS protein fingerprint database

T K Attwood1, M E Beck, A J Bleasby

  • 1Department of Biochemistry, University College London, UK.

Nucleic Acids Research
|January 1, 1996
PubMed
Summary
This summary is machine-generated.

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PRINTS is a protein motif database that uses

Area of Science:

  • Bioinformatics and computational biology
  • Protein sequence analysis
  • Molecular biology databases

Background:

  • Protein families are often characterized by conserved sequence motifs.
  • Existing motif databases can have limitations in diagnostic reliability.
  • The PRINTS database compiles protein motif 'fingerprints' for family identification.

Purpose of the Study:

  • To describe the PRINTS database, a compendium of protein motif fingerprints.
  • To highlight the advantages of using fingerprints over single motifs for protein family classification.
  • To announce the accessibility of the latest version of PRINTS.

Main Methods:

  • Construction of protein motif 'fingerprints' from sequence alignments.
  • Integration of motifs into a comprehensive database (PRINTS).

Related Experiment Videos

  • Utilizing conserved nature of motifs as signatures for family membership.
  • Main Results:

    • PRINTS version 9.0 contains approximately 2000 motifs.
    • The database covers diverse protein types, including globular and membrane proteins.
    • Fingerprints offer enhanced diagnostic reliability through motif context.

    Conclusions:

    • PRINTS provides a valuable resource for protein family identification.
    • The use of motif fingerprints improves accuracy compared to single motif methods.
    • The PRINTS database is accessible via the UCL Bioinformatics server.