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GRBase, a database linking information on proteins involved in gene regulation
1Trevigen Inc., Gaithersburg, MD 20877, USA.
Nucleic Acids Research
|January 1, 1996
Summary
The Gene Regulation Database (GRBase) offers comprehensive eukaryotic gene expression control protein data. This accessible web resource links to other databases, aiding research on transcription factors and signal transduction.
Area of Science:
- Molecular Biology
- Genetics
- Bioinformatics
Background:
- Gene expression regulation is crucial for eukaryotic cellular function.
- Understanding proteins involved in gene regulation is key to deciphering complex biological processes.
- Existing data on these proteins is often fragmented across various resources.
Purpose of the Study:
- To introduce the Gene Regulation Database (GRBase) as a centralized resource.
- To provide comprehensive information on eukaryotic gene expression regulatory proteins.
- To enhance data accessibility and inter-database connectivity for researchers.
Main Methods:
- Compilation of data on eukaryotic gene expression regulatory proteins.
- Development of a web-accessible database (GRBase).
- Implementation of cross-database linking features.
Main Results:
- GRBase provides detailed information on transcription factors, signal transduction proteins, and receptors.
- The database is accessible via the World Wide Web and anonymous FTP.
- Each GRBase entry is linked to relevant data in other biological databases.
Conclusions:
- GRBase serves as a valuable, integrated resource for studying gene regulation.
- Enhanced data linking facilitates more comprehensive research.
- Increased accessibility promotes wider use in eukaryotic gene expression studies.