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REBASE--restriction enzymes and methylases

R J Roberts1, D Macelis

  • 1New England BioLabs, Beverly, MA 01915, USA.

Nucleic Acids Research
|January 1, 1996
PubMed
Summary

REBASE is a comprehensive database for restriction enzymes and methylases, detailing recognition sites and availability. This resource aids molecular biology research and bioinformatics software development.

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Area of Science:

  • Molecular Biology
  • Bioinformatics
  • Genomics

Background:

  • Restriction enzymes and methylases are crucial tools in molecular biology.
  • Accurate and up-to-date information on these enzymes is essential for researchers.
  • Existing data sources may be fragmented or difficult to access.

Purpose of the Study:

  • To present REBASE as a comprehensive database for restriction enzymes and methylases.
  • To detail the types of information included in REBASE, such as recognition and cleavage sites.
  • To highlight the accessibility of REBASE data through various platforms.

Main Methods:

  • Compilation of data on restriction enzymes and methylases.
  • Organization of information including recognition sites, cleavage sites, and commercial availability.
  • Dissemination of data via monthly electronic mailings, WAIS, anonymous FTP, and the World Wide Web.

Main Results:

  • REBASE provides a centralized repository of enzyme information.
  • Data is updated monthly to ensure current information.
  • Specialized files are available for direct use with bioinformatics software.

Conclusions:

  • REBASE serves as an invaluable resource for molecular biologists and bioinformaticians.
  • The database facilitates research by providing easy access to critical enzyme data.
  • REBASE supports the advancement of molecular biology applications through accessible data and software compatibility.

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