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The Ribonuclease P Database

J W Brown1

  • 1Department of Microbiology, North Carolina State University, Raleigh, 27695, USA.

Nucleic Acids Research
|January 1, 1996
PubMed
Summary
This summary is machine-generated.

Ribonuclease P (RP) is an enzyme that processes precursor tRNAs. In bacteria, the RNA component of RP exhibits catalytic activity, acting as a ribozyme for tRNA maturation. The RP Database compiles sequence and structural data for RP worldwide.

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Area of Science:

  • Biochemistry
  • Molecular Biology
  • Bioinformatics

Background:

  • Ribonuclease P (RNase P) is a crucial enzyme in tRNA biogenesis.
  • It functions as an endoribonuclease, cleaving leader sequences from precursor tRNAs (pre-tRNAs).
  • Bacterial RNase P is a ribonucleoprotein where the RNA subunit alone possesses catalytic activity (a ribozyme).

Purpose of the Study:

  • To present the Ribonuclease P Database, a comprehensive resource for RNase P information.
  • To facilitate research on RNase P by providing curated sequence, structure, and model data.
  • To make this information accessible via the World Wide Web.

Main Methods:

  • Compilation of known Ribonuclease P sequences.
  • Generation of sequence alignments.

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  • Development of secondary structure models and 3D models.
  • Integration of accessory information.
  • Publication as a hypertext document on the World Wide Web.

    • Main Results:

    • The Ribonuclease P Database is established as a centralized repository.
    • It contains diverse data including sequences, alignments, and structural models.
    • The database is accessible online, supporting global research efforts.

    Conclusions:

    • The Ribonuclease P Database serves as a valuable resource for studying tRNA processing and ribozymes.
    • Accessibility via the WWW enhances collaboration and data sharing in the field.
    • This compilation aids in understanding the structure-function relationships of RNase P across different organisms.