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Related Experiment Videos

Histone Sequence Database: a compilation of highly-conserved nucleoprotein sequences

A D Baxevanis1, D Landsman

  • 1National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA.

Nucleic Acids Research
|January 1, 1996
PubMed
Summary
This summary is machine-generated.

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This study constructed a comprehensive database of aligned histone protein and nucleotide sequences, including over 1300 entries. The histone fold motif region is identified within core histone alignments.

Area of Science:

  • Molecular Biology
  • Genomics
  • Bioinformatics

Background:

  • Histones are crucial proteins involved in DNA packaging and regulation.
  • Understanding histone sequence conservation is vital for studying gene regulation and evolution.

Purpose of the Study:

  • To create a comprehensive, aligned database of histone protein and nucleotide sequences.
  • To identify conserved regions, specifically the histone fold motif, within core histones.

Main Methods:

  • Utilized protein sequence databases for human and chicken histones (H1/H5, H2A, H2B, H3, H4).
  • Performed sequence similarity searches to construct aligned protein and nucleotide sequence databases.
  • Identified the histone fold motif region in core histone alignments.

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Main Results:

  • Assembled a database containing over 1300 aligned protein and nucleotide sequences.
  • Statistically significant sequence similarity was established for the histone sequences.
  • The histone fold motif region was pinpointed within the core histone protein alignments.

Conclusions:

  • The developed database provides a valuable resource for histone research.
  • Facilitates comparative genomics and evolutionary studies of histones.
  • The identified histone fold motif aids in understanding functional conservation.