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The Signal Recognition Particle Database (SRPDB)

N Larsen1, C Zwieb

  • 1Department of Microbiology, Michigan State University, East Lansing 48824, USA.

Nucleic Acids Research
|January 1, 1996
PubMed
Summary
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The Signal Recognition Particle Database (SRPDB) offers aligned RNA and protein sequences for signal recognition particles. This valuable resource aids researchers studying SRP structure and function.

Area of Science:

  • Molecular Biology
  • Genomics
  • Bioinformatics

Background:

  • Signal Recognition Particle (SRP) pathways are crucial for protein targeting in all cells.
  • Understanding SRP components is essential for deciphering cellular protein trafficking.
  • Existing databases may lack comprehensive, phylogenetically ordered SRP sequence data.

Purpose of the Study:

  • To present an updated and expanded Signal Recognition Particle Database (SRPDB).
  • To provide researchers with aligned, annotated, and phylogenetically ordered SRP RNA and protein sequences.
  • To facilitate comparative analysis and research into SRP evolution and function.

Main Methods:

  • Curated collection and alignment of Signal Recognition Particle RNA sequences.
  • Curated collection and alignment of Signal Recognition Particle protein sequences (SRP9, SRP14, SRP19, SRP21, SRP54, SRP68, SRP72).

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  • Phylogenetic ordering and annotation of all collected sequences.

    • Main Results:

    • The current SRPDB release contains 93 RNA and 29 protein sequences.
    • Sequences are aligned, annotated, and phylogenetically ordered for ease of use.
    • The database is downloadable and accessible online.

    Conclusions:

    • The SRPDB is a comprehensive resource for studying Signal Recognition Particle components.
    • Its accessibility and detailed organization support diverse research applications in molecular biology and genomics.
    • The database serves as a key tool for ongoing research into protein targeting and SRP evolution.