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Related Experiment Videos

Rosette formation by Plasmodium vivax

R Udomsanpetch1, K Thanikkul, S Pukrittayakamee

  • 1Department of Pathobiology, Faculty of Science, Mahidol University, Bangkok, Thailand.

Transactions of the Royal Society of Tropical Medicine and Hygiene
|November 1, 1995
PubMed
Summary
This summary is machine-generated.

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Plasmodium vivax causes malaria but is rarely fatal. Unlike P. falciparum, P. vivax-infected red blood cells do not adhere to endothelial cells, suggesting rosetting alone doesn't cause cerebral malaria.

Area of Science:

  • Malariology
  • Infectious Diseases
  • Immunology

Background:

  • Plasmodium falciparum infections can be fatal due to cytoadherence and rosetting of infected red blood cells.
  • Plasmodium vivax infections are generally less severe than P. falciparum infections.

Purpose of the Study:

  • To investigate the rosetting properties of Plasmodium vivax-infected red blood cells.
  • To compare the adhesive properties of P. vivax-infected cells with P. falciparum.

Main Methods:

  • Studied red blood cells infected with P. vivax from malaria patients in Thailand.
  • Assessed rosetting of infected red blood cells.
  • Evaluated adherence to endothelial cells, melanoma cells, platelets, and CD36.

Main Results:

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  • 71% of P. vivax isolates exhibited rosetting, with a mean of 41% of infected red blood cells involved.
  • Rosetting correlated with parasite maturation but not parasitemia.
  • P. vivax-infected cells did not adhere to endothelial cells, melanoma cells, platelets, or CD36.

Conclusions:

  • Rosetting occurs in P. vivax malaria but differs from P. falciparum.
  • Thrombocytopenia in P. vivax malaria is unlikely due to platelet-red cell attachment.
  • Rosetting alone is insufficient to cause cerebral malaria in P. vivax infections.