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Nonlinear resistances in hepatic microcirculation

R Maass-Moreno1, C F Rothe

  • 1Department of Physiology and Biophysics, Indiana University School of Medicine, Indianapolis 46202, USA.

The American Journal of Physiology
|December 1, 1995
PubMed
Summary
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The liver

Area of Science:

  • Physiology
  • Hepatology
  • Vascular Biology

Background:

  • The liver's capacity to mobilize blood is crucial for circulatory regulation.
  • Understanding pressure transmission dynamics within the liver is essential for comprehending its reservoir function.
  • Nonlinear pressure transmission may limit blood volume redistribution under certain physiological conditions.

Purpose of the Study:

  • To investigate nonlinear pressure transmission from the abdominal vena cava to the hepatic microcirculation.
  • To examine pressure transmission from the hepatic microcirculation to the portal vein.
  • To test for the presence of a Starling resistor-like mechanism in hepatic vasculature.

Main Methods:

  • Utilized a servo-null micropipette technique to measure microvascular pressures on the liver surface of rabbits.

Related Experiment Videos

  • Manipulated downstream (outflow) pressure by partially occluding the caudal thoracic vena cava.
  • Analyzed upstream-downstream pressure relationships to identify 'break pressures'.

    • Main Results:

    • A 'break pressure' phenomenon was observed in 16 of 30 measurements, where hepatic venular pressure increased only after abdominal vena caval pressure exceeded 2.85 ± 0.92 mmHg.
    • In 13 of 31 measurements, portal venous pressure remained unchanged until hepatic venular pressure surpassed a break pressure of 3.36 ± 0.54 mmHg.
    • Similar nonlinear pressure transmission characteristics were noted in sinusoids and portal venules, suggesting a Starling resistor mechanism.

    Conclusions:

    • Significant hepatic resistances with nonlinear characteristics are present both upstream and downstream of central venules, sinusoids, and portal venules.
    • These findings indicate that the liver's microvasculature exhibits properties that can modulate blood flow and volume redistribution.
    • The identified 'break pressure' phenomenon has implications for understanding hepatic hemodynamics and potential interventions.