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Zero flow pressure in human coronary circulation

S Nanto1, T Masuyama, M Hori

  • 1Cardiovascular Division of Kansai Rosai Hospital, Amagasaki, Japan.

Angiology
|February 1, 1996
PubMed
Summary
This summary is machine-generated.

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This study determined the zero flow pressure intercept (Pzf) in humans during cardiac pauses induced by adenosine triphosphate (ATP). The Pzf was found to be higher than expected, suggesting complex factors influence coronary circulation.

Area of Science:

  • Cardiovascular Physiology
  • Coronary Circulation Research
  • Hemodynamics

Background:

  • The coronary pressure-flow (P/F) relationship is typically studied for coronary resistance.
  • Emerging evidence highlights the significance of the zero flow pressure intercept (Pzf) in characterizing coronary circulation.
  • Pzf data in humans is currently unavailable.

Purpose of the Study:

  • To determine the zero flow pressure intercept (Pzf) in human coronary circulation.
  • To analyze the P/F relationship during induced cardiac pauses.
  • To investigate the determinants of Pzf in humans.

Main Methods:

  • Analyzed the P/F relationship in 9 patients with coronary heart disease during induced cardiac pauses.
  • Administered intracoronary adenosine triphosphate (ATP) to provoke cardiac pauses and altered coronary blood flow.

Related Experiment Videos

  • Measured coronary blood flow velocity in the left anterior descending artery using a Doppler angioplasty guide wire.
  • Applied least square linear regression analysis to P/F data to extrapolate Pzf.

    • Main Results:

    • Intracoronary ATP infusion induced a long cardiac pause (5320 +/- 1498 msec) and decreased coronary blood flow velocity (11 +/- 8 cm/sec).
    • The calculated Pzf using the P/F relationship was 14 +/- 7 mmHg.
    • Pzf was observed to be higher than right atrial and left ventricular end-diastolic pressures.

    Conclusions:

    • The study successfully determined Pzf in humans.
    • The findings indicate that Pzf is higher than right atrial and left ventricular end-diastolic pressures.
    • The determinants of Pzf in human coronary circulation are complex.