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[Potentially uropathogenic enterobacteria on the periurethral mucosa of urologically normal individuals (author's
Insights
Enterobacteria are common in the periurethra of young children, decreasing with age. This study explores factors influencing enterobacteria presence in the periurethral flora.
Area of Science:
- Microbiology
- Urology
Context:
- The periurethral area harbors a complex microbial flora.
- Enterobacteria are common causes of urinary tract infections.
Purpose:
- To investigate the prevalence and dynamics of potentially uropathogenic enterobacteria in the periurethral flora of healthy individuals across different age groups.
Summary:
- Enterobacteria were identified in 100% of children aged 0-3 years, with numbers decreasing significantly with age.
- Prevalence in adult women was 15%.
- Findings suggest a dynamic equilibrium of contamination and elimination, with contamination being significant in early childhood, potentially linked to bowel training.
Impact:
- This research provides insights into the developing periurethral microbiome and potential factors influencing uropathogen colonization.
- Understanding these dynamics may inform strategies for preventing urinary tract infections.
Abstract:
Swabs from the periurethra from 160 urologically normal individuals, male and female, of various age groups were examined for potentially uropathogenic enterobacteria. Children from 0--3 years constantly showed (100%) high numbers of different enterobacteria. The frequency of identification and the number of these bacteria diminished abruptly with advancing age. In adult women we found a prevalence of 15%. The periurethral flora with regard to enterobacteria is probably the result of a dynamic equilibrium between contamination and elimination. The important role of contamination is documented by the massive seeding in the 0--3 years age group and the abrupt diminuition after successful bowel training. The mechanism of elimination is unknown. Personal hygiene, the pH of the periurethral mucosa, a special antibacterial substance and the ecological equilibrium of the periurethral flora are discussed as possible factors.