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Engineering liposomes for drug delivery: progress and problems
1Centre for Drug Delivery Research, School of Pharmacy, University of London, UK.
Trends in Biotechnology
|December 1, 1995
Summary
Liposomes, used as drug delivery systems for 25 years, have advanced significantly. Modern liposome technology enables rational design for disease treatment and prevention, including licensed therapies and vaccines.
Area of Science:
- Biotechnology
- Nanomedicine
- Pharmacology
Background:
- Liposomes were initially explored as drug delivery systems over two decades ago.
- Significant progress has been made in understanding liposome behavior in vivo at cellular and subcellular levels.
Purpose of the Study:
- To review the advancements in liposome technology and applications.
- To highlight the development of liposome-based therapeutics and vaccines.
Main Methods:
- Review of scientific literature and industry developments.
- Analysis of technological progress in liposome formulation and application.
Main Results:
- Rational design of liposomes for disease treatment and prevention is now possible.
- Liposome-based formulations are licensed for treating microbial infections and cancers.
- The first liposome-based human vaccine has been developed.
Conclusions:
- Liposome technology has matured, leading to successful clinical and commercial applications.
- Continued research and development promise further expansion of liposome-based therapies and preventative measures.