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Related Experiment Videos

Rush immunotherapy: experience with a one-day schedule

P Sharkey1, J Portnoy

  • 1Section of Allergy/Asthma/Immunology, The Children's Mercy Hospital, Kansas City, Missouri, USA.

Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology
|February 1, 1996
PubMed
Summary
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A new one-day rush immunotherapy protocol effectively desensitizes patients to inhalant allergens. This rapid method is safe and convenient, achieving maintenance doses faster than traditional approaches.

Area of Science:

  • Allergy and Immunology
  • Clinical Medicine

Background:

  • Rush immunotherapy rapidly desensitizes patients to allergens.
  • Existing protocols are inconvenient (1.5 days).
  • A novel 1-day protocol was developed to improve convenience and reduce costs.

Purpose of the Study:

  • To evaluate the safety and efficacy of a new 1-day rush immunotherapy protocol.
  • To compare reaction rates with conventional immunotherapy.
  • To assess the feasibility of reaching maintenance doses within one day.

Main Methods:

  • 22 allergic patients received 8 injections over 6 hours with 2 hours observation.
  • Patients with rhinitis and asthma (including steroid-dependent) were included.
  • Premedication included astemizole, ranitidine, and prednisone; peak expiratory flow was monitored.

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Main Results:

  • 23% (5/22) experienced systemic reactions, primarily rhinitis or pulmonary symptoms.
  • One mild anaphylaxis occurred; most reactions were mild and responded to epinephrine.
  • All patients reached maintenance doses within one day, significantly faster than weekly schedules.

Conclusions:

  • The 1-day rush immunotherapy protocol is well-tolerated and safe.
  • It offers a comparable systemic reaction rate to conventional immunotherapy.
  • This protocol enhances convenience and reduces costs for allergen desensitization.