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Related Experiment Videos

Post-tetanic burst count: a stimulating pattern for profound neuromuscular blockade

Y Saitoh1, Y Fujii, H Toyooka

  • 1Department of Anesthesiology and Critical Care Medicine, Faculty of Medicine, Tokyo Medical and Dental University, Japan.

Canadian Journal of Anaesthesia = Journal Canadien D'Anesthesie
|December 1, 1995
PubMed
Summary

The post-tetanic burst count (PTBC) provides a more sensitive measure of neuromuscular blockade recovery than the post-tetanic count (PTC). PTBC allows for evaluation of deeper neuromuscular blockade levels compared to PTC.

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Retraction notice to "Recoveries of post-tetanic twitch and train-of-four responses after administration of vecuronium with different inhalation anaesthetics and neuroleptanaesthesia" [Br J Anaesth 1993; 70: 402-404].

British journal of anaesthesia·2018
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Retraction notice to "Relationship between post-tetanic twitch and single twitch response after administration of vecuronium" [Br J Anaesth 1993; 71: 443-444].

British journal of anaesthesia·2018
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Retraction notice to "Post-tetanic count and single twitch height at the onset of reflex movement after administration of vecuronium under different types of anaesthesia" [Br J Anaesth 1994; 72: 688-690].

British journal of anaesthesia·2018
Same author

Retraction notice to "Effect of tetanic stimulation on subsequent train-of-four responses at various levels of vecuronium-induced neuromuscular block" [Br J Anaesth 1994; 73: 416-417].

British journal of anaesthesia·2018
Same author

Retraction notice to "Post-tetanic burst: a new monitoring method for intense neuromuscular block" [Br J Anaesth 1995; 74: 293-295].

British journal of anaesthesia·2018
Same author

RETRACTED ARTICLE: Dobutamine increases contractility of fatigued diaphragm in dogs: The relationship between dose and diaphragmatic contractility.

Journal of anesthesia·2013

Area of Science:

  • Anesthesiology
  • Pharmacology
  • Physiology

Background:

  • Neuromuscular blockade is crucial in anesthesia for facilitating intubation and surgery.
  • Monitoring neuromuscular recovery is essential to prevent postoperative residual paralysis.
  • Current monitoring methods may have limitations in assessing profound neuromuscular blockade.

Purpose of the Study:

  • To compare the recovery patterns from vecuronium-induced neuromuscular blockade using post-tetanic burst count (PTBC) and post-tetanic count (PTC).
  • To investigate the relationship between PTBC, PTC, and T1 (first response in train-of-four stimulation).
  • To determine if PTBC offers an advantage over PTC or TOF in evaluating intense neuromuscular blockade.

Main Methods:

  • Sixty adult patients undergoing nitrous oxide-oxygen-isoflurane anesthesia were studied.

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  • Vecuronium 0.07 mg.kg-1 was administered to induce neuromuscular blockade.
  • Neuromuscular blockade was monitored using an accelerometer to measure PTBC and PTC, alongside train-of-four (TOF) stimulation.

    • Main Results:

    • PTBC was significantly greater than PTC during the 15-35 minute interval post-vecuronium administration (P < 0.05).
    • The time to return of PTBC response was shorter than that of PTC (17.7 vs 22.7 min, P = 0.0005).
    • At the return of T1, PTBC values remained higher than PTC values (14.3 vs 9.4, P = 0.0153), indicating a more profound blockade assessment with PTBC.

    Conclusions:

    • Post-tetanic burst count (PTBC) allows for a more profound evaluation of neuromuscular blockade compared to post-tetanic count (PTC).
    • PTBC may be advantageous in assessing the depth of neuromuscular blockade, especially during intense blockade states.
    • These findings suggest PTBC could enhance the safety and efficacy of neuromuscular blockade monitoring in clinical anesthesia.