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Right and left atrial phasic volumetric function in mildly symptomatic dilated and hypertrophic cardiomyopathy: cine
V M Järvinen1, M M Kupari, V P Poutanen
1Department of Diagnostic Radiology, Helsinki University Central Hospital, Finland.
Insights
Dilated and hypertrophic cardiomyopathy enlarge the left atrium and reduce its volume changes. Cine magnetic resonance (MR) imaging reveals compromised right atrial function, particularly in dilated cardiomyopathy.
Area of Science:
- Cardiology
- Medical Imaging
- Biomedical Engineering
Background:
- Cardiomyopathy, including dilated and hypertrophic types, significantly impacts cardiac function.
- Atrial function plays a crucial role in overall cardiovascular health.
- Understanding atrial volumetric changes is key to diagnosing and managing heart conditions.
Purpose of the Study:
- To characterize biatrial phasic volumetric function in dilated and hypertrophic cardiomyopathy.
- To compare atrial function in cardiomyopathy patients with healthy controls.
- To assess the utility of cine magnetic resonance (MR) imaging in evaluating atrial function.
Main Methods:
- Eight patients with dilated cardiomyopathy, eight with hypertrophic cardiomyopathy, and eight healthy controls underwent cardiac-gated long-axis cine MR imaging.
- Three-dimensional volume measurements were obtained for both atria.
- Phasic volumetric function parameters were analyzed.
Main Results:
- Left atrial minimum volume was significantly larger in both dilated (94 mL) and hypertrophic (86 mL) cardiomyopathy groups compared to controls (51 mL).
- Left atrial ejection fraction was reduced in dilated (16%) and hypertrophic (19%) cardiomyopathy groups versus controls (28%).
- Normalized filling and emptying rates of both atria were decreased in both cardiomyopathy groups.
Conclusions:
- Mildly symptomatic dilated and hypertrophic cardiomyopathy are associated with left atrial enlargement and reduced cyclic volume changes.
- The right atrium, while normal in size, exhibits compromised reservoir function, especially in dilated cardiomyopathy.
- Cine MR imaging provides valuable three-dimensional insights into altered atrial volumetric function in cardiomyopathy.
Purpose:
To characterize biatrial phasic volumetric function in dilated and hypertrophic cardiomyopathy with cine magnetic resonance (MR) imaging.
Materials And Methods:
Eight patients with dilated cardiomyopathy (mean age, 47 years), eight with hypertrophic cardiomyopathy (mean age, 39 years), and eight healthy subjects (mean age, 41 years) underwent cardiac-gated long-axis cine MR imaging of both atria.
Results:
Left atrial minimum volume averaged 94 mL +/- 37 (standard deviation) in dilated cardiomyopathy, 86 mL +/- 40 in hypertrophic cardiomyopathy, and 51 mL +/- 14 in control subjects (P = .04). Left atrial ejection fraction averaged 16% +/- 6 in dilated cardiomyopathy, 19% +/- 12 in hypertrophic cardiomyopathy, and 28% +/- 7 in control subjects (P = .03). Right atrial minimum volume and ejection fraction were not altered in either form of cardiomyopathy. The normalized filling and emptying rates of either atrium were decreased in both forms of cardiomyopathy.
Conclusion:
In mildly symptomatic dilated and hypertrophic cardiomyopathy, and left atrium is enlarged and its relative cyclic volume changes are reduced. The right atrium is of normal size, but its reservoir function is compromised particularly in dilated cardiomyopathy. Three-dimensional volume measurements with cine MR imaging enable the exposure of altered atrial volumetric function.