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Receptor-mediated toxicity

J A Gustafsson1

  • 1Karolinska Institutet, Department of Medical Nutrition, Novum, Huddinge, Sweden.

Toxicology Letters
|December 1, 1995
PubMed
Summary
This summary is machine-generated.

This study explores soluble intracellular receptors that mediate toxic responses. Specific examples include the glucocorticoid receptor, peroxisome proliferator activated receptor (PPAR), and the dioxin receptor, highlighting their roles in toxicity and tissue accumulation.

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Area of Science:

  • Toxicology
  • Molecular Biology
  • Biochemistry

Background:

  • Toxic agents often bind to specific receptors with high affinity.
  • Soluble intracellular receptors play a key role in mediating toxicological responses.
  • Understanding these receptor-mediated toxicities is crucial for risk assessment.

Purpose of the Study:

  • To discuss soluble intracellular receptors involved in mediating toxic responses.
  • To provide examples of specific receptors and their associated toxicological effects.
  • To highlight mechanisms of tissue-specific accumulation of toxic metabolites.

Main Methods:

  • Literature review and discussion of known soluble intracellular receptors.
  • Analysis of receptor-specific toxicological pathways.

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  • Examination of case studies involving specific toxic agents and their receptors.

    • Main Results:

    • The glucocorticoid receptor serves as a model and is implicated in lymphocyte apoptosis and neuronal degeneration.
    • Peroxisome proliferator activated receptor (PPAR) is linked to hepatocarcinogenesis in rodents.
    • The dioxin receptor mediates a broad spectrum of toxic effects, and a mechanism for tissue-specific accumulation of a polychlorinated biphenyl metabolite is presented.

    Conclusions:

    • Soluble intracellular receptors are critical mediators of toxicity for specific agents.
    • Receptor-mediated toxicity encompasses diverse effects, including cell death, cancer, and tissue accumulation.
    • Further research into these pathways can inform strategies for mitigating toxicological risks.