Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Environmentally induced asthma

M J Utell1, R J Looney

  • 1University of Rochester Medical Center, Department of Medicine, NY 14642, USA.

Toxicology Letters
|December 1, 1995
PubMed
Summary

Asthma is increasingly prevalent, with environmental factors like air pollution and indoor allergens playing a key role. Reducing exposure to allergens such as house dust mite can significantly improve asthma symptoms and airway responsiveness.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ultrafine Particle Concentrations in a Hospital.

Inhalation toxicology·2015
Same author

Variability in the biological response to anti-CD20 B cell depletion in systemic lupus erythaematosus.

Annals of the rheumatic diseases·2008
Same author

B cells as a therapeutic target in autoimmune diseases other than rheumatoid arthritis.

Rheumatology (Oxford, England)·2005
Same author

Panel discussion on B cells and rituximab: mechanistic aspects, efficacy and safety in rheumatoid arthritis and non-Hodgkin's lymphoma.

Rheumatology (Oxford, England)·2005
Same author

Bone implant interface, osteolysis and potential therapies.

Journal of musculoskeletal & neuronal interactions·2005
Same author

RANK, RANKL and OPG in inflammatory arthritis and periprosthetic osteolysis.

Journal of musculoskeletal & neuronal interactions·2004

Area of Science:

  • Environmental Health
  • Pulmonology
  • Allergy Immunology

Background:

  • Asthma is a chronic respiratory condition marked by airway inflammation and obstruction.
  • Despite treatment advances, asthma prevalence and mortality rates are rising globally.
  • Environmental factors, including air pollutants and allergens, are significant contributors to asthma development and exacerbation.

Purpose of the Study:

  • To review the role of environmental factors in asthma development and exacerbation.
  • To highlight the impact of air pollutants and indoor allergens on asthma.
  • To discuss the effectiveness of allergen avoidance strategies.

Main Methods:

  • Review of controlled human chamber studies on pollutant exposure.
  • Analysis of epidemiological data on asthma prevalence and risk factors.
  • Examination of clinical studies on allergen avoidance interventions.

Main Results:

  • Asthmatics exhibit heightened susceptibility to outdoor pollutants (e.g., sulfur dioxide, nitrogen dioxide) and indoor allergens.
  • Exposure to indoor allergens like house dust mite is causally linked to asthma.
  • Allergen avoidance, particularly for house dust mite, leads to reduced clinical symptoms and bronchial hyperresponsiveness.

Conclusions:

  • Environmental factors, including air pollution and indoor allergens, are critical in triggering and worsening asthma.
  • Effective management strategies involve minimizing exposure to environmental triggers.
  • Further research is needed to understand the interaction between aeroallergens and air pollutants in asthma.

Related Experiment Videos