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Cord blood transplantation and the potential for gene therapy. Gene transduction using a recombinant adeno-associated
H E Broxmeyer1, S Cooper, M Etienne-Julan
1Department of Medicine (Hematology/Oncology), Walther Oncology Center, Indianapolis, Indiana 46202-5121, USA.
Annals of the New York Academy of Sciences
|December 29, 1995
Abstract:
Cord blood, which contains a high frequency of immature stem/progenitor cells with extensive proliferative and replating capacity in vitro was used as a clinical source of transplantable stem and progenitor cells. These cells can be efficiently transduced with new genetic material by using AAV or retroviral vectors. Using a recombinant AAV vector, high level expression of the lacZ gene under a CMV promoter was demonstrated in immature subsets of cord blood progenitor cells.