Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hypercortisolism and obesity

P M Peeke1, G P Chrousos

  • 1Developmental Endocrinology Branch, National Institutes of Health, Bethesda, Maryland 20892, USA.

Annals of the New York Academy of Sciences
|December 29, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Adrenal cancer.

Endocrinology and metabolism clinics of North America·2000
Same author

Endocrine response to high-intensity exercise: dose-dependent effects of dexamethasone.

The Journal of clinical endocrinology and metabolism·2000
Same author

Sleep apnea and daytime sleepiness and fatigue: relation to visceral obesity, insulin resistance, and hypercytokinemia.

The Journal of clinical endocrinology and metabolism·2000
Same author

Do glucocorticoids cause spinal epidural lipomatosis? When endocrinology and spinal surgery meet.

Trends in endocrinology and metabolism: TEM·2000
Same author

Caffeic acid phenethyl ester induces leukocyte apoptosis, modulates nuclear factor-kappa B and suppresses acute inflammation.

Neuroimmunomodulation·2000
Same author

Inhibition of Th1 immune response by glucocorticoids: dexamethasone selectively inhibits IL-12-induced Stat4 phosphorylation in T lymphocytes.

Journal of immunology (Baltimore, Md. : 1950)·2000
Same journal

Multiomics Profiling During Autoimmune Demyelination Highlights a Complex Regulatory Role for Ataxin-1 in B Cells.

Annals of the New York Academy of Sciences·2026
Same journal

Global Trends in Light Pollution and Their Relationship With Socioeconomic Factors.

Annals of the New York Academy of Sciences·2026
Same journal

Wired for Corruption: Inter-Brain Synchrony Encodes Bribery-Related Value Information and Predicts Bribery Agreement.

Annals of the New York Academy of Sciences·2026
Same journal

LM-YOLO: A Lightweight Multi-Scale Enhanced Model for Forest Smoke Detection Using Unmanned Aerial Vehicles.

Annals of the New York Academy of Sciences·2026
Same journal

Polyrhythm Perception and Production: A Scoping Review.

Annals of the New York Academy of Sciences·2026
Same journal

DARTS-CNN-BiLSTM: Intelligent Fault Diagnosis for Computer Numerical Control Machine Tool Feed System.

Annals of the New York Academy of Sciences·2026
See all related articles

Excess visceral fat, linked to metabolic syndrome, increases disease risk. Chronic stress impacts body composition, affecting health and survival.

Area of Science:

  • Endocrinology
  • Metabolic Health
  • Obesity Research

Background:

  • Obesity is a complex condition where fat distribution impacts health risks.
  • Visceral fat, or intra-abdominal fat, is strongly linked to cardiocerebrovascular disease, diabetes, and mortality.
  • Visceral adiposity is associated with metabolic syndrome, characterized by hypertension, hyperlipidemia, hyperinsulinemia, and insulin resistance.

Purpose of the Study:

  • To explore the relationship between the stress axis, glucocorticoids, and energy metabolism.
  • To understand how chronic stress influences body composition and related health outcomes.

Main Methods:

  • Review of existing literature on obesity, fat distribution, and the stress axis.
  • Analysis of the role of glucocorticoids in energy storage and metabolism.

Related Experiment Videos

  • Examination of the interconnections between the stress, growth, and reproductive axes.

    • Main Results:

    • Visceral fat accumulation is a key determinant of metabolic syndrome and associated diseases.
    • Cushing's syndrome, marked by hypercortisolism, exemplifies the link between excess glucocorticoids, visceral adiposity, and metabolic disturbances.
    • The stress axis significantly influences adipose tissue and overall body composition.

    Conclusions:

    • Excess glucocorticoids, often due to stress axis activation, profoundly affect energy metabolism and fat storage.
    • Chronic stress, both psychological and physical, alters body composition, impacting organismal longevity and survival.
    • Understanding the stress axis's role in adiposity is crucial for managing obesity-related diseases.