[Insulin receptor]
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Updated: Oct 3, 2026

Studying the Hypothalamic Insulin Signal to Peripheral Glucose Intolerance with a Continuous Drug Infusion System into the Mouse Brain
Published on: January 4, 2018
Abstract:
The cloning of the insulin receptor not only established the primary structure of this membrane-bound glycoprotein but also offered the material necessary for the study of the molecular functions of this tyrosine-kinase receptor using molecular biology tools. This short review will summarize the actual knowledge of the structure, the functions (molecular structure of the binding site, tyrosine-kinase functions and role of autophosphorylation) and of the pathology of this receptor in extreme insulin resistances and type II diabetes.
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