Related Experiment Videos
Congenital polyvalvular cardiac disease without chromosomal abnormalities
A Kowal-Vern1, S Bharati, A Melnyk
1Department of Pathology, Loyola University Medical Center, Maywood, Illinois 60153, USA.
Summary
Congenital polyvalvular cardiac disease, often linked to trisomies, shows similar valve abnormalities whether or not chromosomal abnormalities are present. This complex heart condition typically involves other cardiac and extracardiac anomalies.
Area of Science:
- Cardiology
- Genetics
- Developmental Biology
Background:
- Congenital polyvalvular cardiac disease (PVCD) is frequently associated with chromosomal abnormalities, particularly trisomies 18, 13, and 15.
- Trisomy 18 presents a high incidence of PVCD, with up to 93% of patients affected and 34% involving all four heart valves.