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Related Experiment Videos

Effect of renal function on serum nitrogen oxide concentrations

I M Mackenzie1, A Ekangaki, J D Young

  • 1Department of Intensive Care, Royal North Shore Hospital, Sydney, Australia.

Clinical Chemistry
|March 1, 1996
PubMed
Summary

Serum nitrogen oxides (sNOx) reflect nitric oxide production but are affected by kidney function. This study found a strong correlation between sNOx and creatinine, indicating renal function significantly impacts sNOx levels.

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Area of Science:

  • Biochemistry
  • Nephrology
  • Critical Care Medicine

Background:

  • Nitric oxide (NO) is a crucial signaling molecule, but its short in vivo half-life necessitates indirect measurement via stable oxidation products: nitrites and nitrates.
  • Serum nitrogen oxides (sNOx) are commonly used to estimate NO production, assuming consistent renal elimination.
  • The influence of renal function on serum NOx concentrations remains largely uncharacterized.

Purpose of the Study:

  • To investigate the relationship between renal function and serum nitrogen oxides (sNOx) concentrations in critically ill patients.
  • To determine if creatinine clearance, a marker of renal function, affects sNOx levels.

Main Methods:

  • Serum and urine nitrates + nitrites (sNOx) were measured in 71 Intensive Therapy Unit patients.

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  • Nitrogen oxide (NOx) clearance and creatinine clearance were calculated.
  • Statistical analysis was performed to correlate sNOx with creatinine levels.

    • Main Results:

    • A strong and highly significant positive correlation was observed between serum nitrogen oxides (sNOx) and plasma creatinine (P <0.001).
    • This indicates that impaired renal function leads to increased sNOx concentrations.

    Conclusions:

    • Renal function significantly impacts serum nitrogen oxides (sNOx) concentrations.
    • Interpreting sNOx as an index of nitric oxide production requires accounting for the patient's renal function status.
    • Future studies measuring sNOx should consider renal parameters to ensure accurate assessment of nitric oxide production.