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Impairment of mobility in endodermal cells by FAK deficiency
1Department of Morphogenesis, Kumamoto University School of Medicine, Japan.
Experimental Cell Research
|February 1, 1996
Abstract:
Focal adhesion kinase (FAK) is a novel nonreceptor protein tyrosine kinase that localizes in focal adhesions. It is expressed in a variety of cell types, and we reported earlier that is deficiency causes a decrease of mobility in mesodermal cells with enhanced formation of focal adhesions. With embryoid bodies generated from embryonic stem cells, we also observed a decrease of mobility in FAK-deficient endodermal cells with enhanced focal adhesion formation.