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[Chronic constipation. Use of cisapride]
A Uzcategui Arauz1, Y Arias Guzman, D Jaen
1Sevicio de Gastroenterología, Hospital General del Oeste Dr. José Gregorio Hernández Magallanes de Catia, Caracas, Venezuela.
G.E.N
|July 1, 1995
Summary
Cisapride significantly improved bowel movement frequency and consistency in chronic constipation patients. This drug also shortened transit time and enhanced rectoanal manometry readings, indicating better intestinal motility.
Area of Science:
- Gastroenterology
- Pharmacology
Background:
- Chronic constipation affects a significant portion of the population, impacting quality of life.
- Current treatments for chronic constipation have limitations and varying efficacy.
Purpose of the Study:
- To evaluate the efficacy of Cisapride in improving evacuation characteristics, orocoecal transit time, and rectoanal manometry parameters in patients with chronic constipation.
Main Methods:
- A randomized, double-blind, placebo-controlled, crossed study involving 51 patients with chronic constipation.
- Patients received Cisapride (10 mg orally every 8 hours) or placebo for two 30-day phases.
- Assessments included clinical evaluation, rectoanal manometry, and hydrogen breath tests.
Main Results:
- Cisapride significantly increased evacuation rhythm (p < 0.05) and improved stool consistency (p < 0.05).
- Orocecal transit time was shortened with Cisapride treatment (p < 0.05).
- Rectoanal manometry showed improved internal anal sphincter pressure and relaxation percentage with Cisapride (p < 0.05).
Conclusions:
- Cisapride demonstrates significant efficacy in improving intestinal motility in patients suffering from chronic constipation.
- The drug was well-tolerated with no significant side effects reported.
- Cisapride represents a viable therapeutic option for managing chronic constipation.