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MR perfusion studies with T1-weighted echo planar imaging

K K Kwong¹, D A Chesler, R M Weisskoff

¹MGH-NMR Center, Department of Radiology, Massachusetts General Hospital, Charlestown 02129, USA.

Magnetic Resonance in Medicine

|December 1, 1995

Summary

A new T1 perfusion model accurately measures steady-state brain blood flow using selective inversion pulses. This method enhances gray-white matter contrast and provides preliminary blood flow maps, addressing key accuracy challenges.

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Area of Science:

Neuroimaging
Physiology
Medical Physics

Background:

The T1 perfusion model is established for brain functional studies measuring flow changes.
Accurate quantification of steady-state brain blood flow remains a challenge in neuroimaging.

Purpose of the Study:

To develop and validate a novel method for studying steady-state brain blood flow using selective and nonselective inversion pulses.
To improve gray-white matter flow contrast in brain blood flow mapping.

Main Methods:

Acquisition of flow-sensitive images via selective inversion and flow-insensitive images via nonselective inversion.
Subtraction of flow-insensitive from flow-sensitive images to generate flow-weighted images.
Fitting T1 values from both image types to derive preliminary brain blood flow maps.

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Main Results:

Flow-weighted images demonstrated good gray-white matter flow contrast in cortical gray matter, thalamus, and basal ganglia.
Preliminary brain blood flow maps were obtained by fitting T1 values.
Identified partial volume effects and T1 differences as critical factors affecting accuracy.

Conclusions:

The developed T1 perfusion method shows promise for quantifying steady-state brain blood flow with improved contrast.
Addressing partial volume effects and T1 differences is crucial for accurate blood flow quantification.
The method provides a foundation for more precise brain blood flow assessment in clinical and research settings.