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Hypervitaminosis A as a complication of treatment for neuroblastoma
L E Grissom1, G C Griffin, G A Mandell
1Department of Medical Imaging, Alfred I. duPont Institute, 1600 Rockland Road, Wilmington, DE 19803, USA.
Abstract:
A case of hypervitaminosis A (HVA) as a complication of therapy for stage-IV neuroblastoma is presented. The patient was randomized to a trial of 13-cis -retinoic acid (a vitamin A-related compound) after completing routine chemotherapy. This acid was given as a means of maturing potential minimal residual disease. A routine follow-up bone scan revealed areas of increased activity, initially along the midshaft of the right ulna and subsequently bilaterally, which were ultimately found to be due to HVA. Hypervitaminosis A has not been previously reported in this setting, and awareness of the condition is important in centers where this treatment is contemplated.
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