Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The platelet functions in stroke

D Krajícková1, J Malý, M Pecka

  • 1Department of Neurology, University Hospital, Hradec Králové.

Sbornik Vedeckych Praci Lekarske Fakulty Karlovy University V Hradci Kralove
|January 1, 1993
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Efficacy and safety of urgent carotid endarterectomy in patients with acute ischemic stroke.

Rozhledy v chirurgii : mesicnik Ceskoslovenske chirurgicke spolecnosti·2022
Same author

Plant extracellular vesicles and their potential in human health research, the practical approach.

Physiological research·2022
Same author

Effects of Acute Pump Speed Changes on Cerebral Hemodynamics in Patients With an Implantable Continuous-Flow Left Ventricular Assist Devices.

Physiological research·2021
Same author

Representative sample survey on factors determining the Czech physicians' awareness of generic drugs and substitution.

BMC health services research·2019
Same author

Combined endovascular and surgical treatment of symptomatic tandem occlusion of common carotid artery and middle cerebral artery - case repor.

Rozhledy v chirurgii : mesicnik Ceskoslovenske chirurgicke spolecnosti·2019
Same author

Intraventricular placement of a spring expander does not attenuate cardiac atrophy of the healthy heart induced by unloading via heterotopic heart transplantation.

Physiological research·2019

Elevated levels of platelet factor 4 (PF4) indicate patients at risk for thrombotic events, rather than a direct sign of cerebral complications in ischemic stroke patients. This finding highlights PF4 as a marker for platelet activation status.

Area of Science:

  • Cardiovascular Medicine
  • Neurology
  • Hematology

Background:

  • Platelet activation plays a crucial role in atherosclerosis and thrombotic complications.
  • Platelet factor 4 (PF4) levels can serve as a biomarker for platelet activation.

Purpose of the Study:

  • To investigate the correlation between plasmatic PF4 levels, clinical presentation, and etiopathogenesis in ischemic stroke patients.
  • To determine if elevated PF4 levels are indicative of cerebral complications or a marker of heightened thrombotic risk.

Main Methods:

  • Measurement of plasmatic PF4 levels in 68 patients diagnosed with ischemic stroke.
  • Analysis of the relationship between PF4 levels and the clinical picture and suspected causes of the stroke.

Main Results:

Related Experiment Videos

  • Increased PF4 levels were observed in the study group.
  • Elevated PF4 levels did not correlate with the presence of cerebral complications.
  • Higher PF4 levels were associated with the patient group characterized by a specific platelet function status, indicating increased risk.

Conclusions:

  • Elevated PF4 levels are not a direct indicator of cerebral complications in ischemic stroke.
  • Increased PF4 levels serve as a marker identifying patients at risk due to their platelet function.
  • The findings suggest PF4 is valuable for assessing thrombotic risk in ischemic stroke patients.