Eccrine syringofibroadenoma. A clear-cell variant

Area of Science:

• Dermatopathology
• Oncology
• Histology

Background:

• Eccrine syringofibroadenoma is a rare benign adnexal neoplasm.
• It originates from the acral portion of the eccrine sweat duct.

Observation:

• This case report details a rare histologic variant of eccrine syringofibroadenoma.
• The variant exhibits nests of periodic acid Schiff-positive clear cells.

Findings:

• The observed clear-cell nests mimic those found in the clear-cell variant of eccrine syringoma.
• This finding expands the known histologic spectrum of eccrine syringofibroadenoma.

Implications:

• Recognizing this variant is crucial for accurate diagnosis and differential diagnosis.
• Further research may elucidate the specific cellular origin and behavior of this clear-cell variant.