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Eccrine syringofibroadenoma. A clear-cell variant

D F Fretzin¹, J B Sloan, K Beer

¹Department of Pathology, Michael Reese Hospital and Medical Center, Chicago, Illinois 60616, USA.

The American Journal of Dermatopathology

|December 1, 1995

Summary

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Eccrine syringofibroadenoma, a rare skin tumor, presents a unique variant with clear cells. This histologic subtype resembles the clear-cell variant of eccrine syringoma.

Area of Science:

Dermatopathology
Oncology
Histology

Background:

Eccrine syringofibroadenoma is a rare benign adnexal neoplasm.
It originates from the acral portion of the eccrine sweat duct.

Observation:

This case report details a rare histologic variant of eccrine syringofibroadenoma.
The variant exhibits nests of periodic acid Schiff-positive clear cells.

Findings:

The observed clear-cell nests mimic those found in the clear-cell variant of eccrine syringoma.
This finding expands the known histologic spectrum of eccrine syringofibroadenoma.

Implications:

Recognizing this variant is crucial for accurate diagnosis and differential diagnosis.

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Further research may elucidate the specific cellular origin and behavior of this clear-cell variant.