Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Drug trials in neuropathy

R A Hughes1, P Heywood, B Sharrack

  • 1Guy's Hospital, Department of Neurology, UMDS, London, UK.

Bailliere'S Clinical Neurology
|November 1, 1995
PubMed
Summary

Peripheral neuropathy drug trials often focus on impairment, neglecting disability and handicap measures. Future research should incorporate these broader outcomes for a comprehensive assessment of treatment effectiveness.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Autologous haematopoietic stem cell transplantation as a first-line disease-modifying therapy in patients with 'aggressive' multiple sclerosis.

Multiple sclerosis (Houndmills, Basingstoke, England)·2021
Same author

WITHDRAWN: Assessment of the inter-laboratory repeatability of gait analysis measurements in patients with multiple sclerosis.

Gait & posture·2021
Same author

Evaluating the clinical effectiveness of autologous haematopoietic stem cell transplantation versus disease-modifying therapy in multiple sclerosis using a matching-adjusted indirect comparison: an exploratory study from the Autoimmune Diseases Working Party (ADWP) of the European Society of Bone and Marrow Transplantation (EBMT).

Bone marrow transplantation·2019
Same author

Gold nanoparticle-based colorimetric biosensors.

Nanoscale·2017
Same author

Visual Outcomes from Shunting for Idiopathic Intracranial Hypertension.

Neuro-ophthalmology (Aeolus Press)·2016
Same author

Corrigendum to "An amino acid depleted cell-free protein synthesis system for the incorporation of non-canonical amino acid analogs into proteins" [J. Biotechnol. 178 (2014) 12-22].

Journal of biotechnology·2016

Area of Science:

  • Neurology
  • Clinical Trials
  • Pharmacology

Background:

  • Peripheral neuropathy drug trials utilize diverse outcome measures.
  • Current trials predominantly assess impairment, with limited focus on disability or handicap.

Purpose of the Study:

  • To review outcome measures in peripheral neuropathy drug trials.
  • To highlight the underutilization of disability and handicap measures.
  • To advocate for the inclusion of broader outcome measures in future studies.

Main Methods:

  • Literature review of drug trials in peripheral neuropathy.
  • Analysis of outcome measures used in inflammatory (GBS, CIDP), diabetic, paraproteinaemic, and toxic neuropathies.
  • Discussion of therapeutic approaches documented in the literature.

Main Results:

  • Most published trials prioritize impairment measures due to their sensitivity.
  • Few trials have incorporated measures of disability or handicap.
  • Various therapeutic strategies have been employed across different neuropathy types.

Conclusions:

  • Outcome measure selection in peripheral neuropathy trials is guided by neuropathy type and study hypothesis.
  • Future drug trials should expand their focus to include disability and handicap measures for a more holistic evaluation.

Related Experiment Videos