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Related Experiment Videos

Soft tissue sarcomas in dermatology

F S Fish1

  • 1Department of Dermatology/Cutaneous Surgery, St. Paul Ramsey Medical Center, MN 55101, USA.

Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [Et Al.]
|March 1, 1996
PubMed
Summary
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Dermatofibrosarcoma protuberans, atypical fibroxanthoma, and cutaneous leiomyosarcoma are rare soft tissue sarcomas with high recurrence rates. Mohs micrographic surgery offers a promising approach for effective treatment and improved outcomes.

Area of Science:

  • Oncology
  • Dermatology
  • Surgical Pathology

Background:

  • Dermatofibrosarcoma protuberans (DFSP), atypical fibroxanthoma (AFX), and cutaneous leiomyosarcoma (CLS) are uncommon soft tissue sarcomas.
  • These tumors exhibit high recurrence rates after standard excisional surgery and potential for metastasis.
  • Current diagnostic and treatment strategies for these neoplasms are continually evolving.

Purpose of the Study:

  • To review the existing surgical, medical, and pathology literature on DFSP, AFX, and CLS.
  • To collate observations from multiple investigators regarding diagnosis and treatment.
  • To summarize effective surgical techniques for managing these challenging tumors.

Main Methods:

  • Extensive literature review of medical journals and textbooks.

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  • Emphasis on diagnostic criteria, histological features, and immunohistochemistry.
  • Analysis of surgical techniques, including margin control and Mohs micrographic surgery.

    • Main Results:

    • DFSP shows high recurrence; wide excision (3-cm margin) is effective but not always practical. Mohs surgery is emerging as a preferred treatment.
    • AFX, a superficial variant of malignant fibrous histiocytoma, requires surgical removal with adequate margins (1-cm for smaller tumors). Mohs surgery is effective for tissue conservation.
    • CLS, a rare sarcoma, has high recurrence and metastatic potential. Wide local excision (3-5 cm margins) with subcutaneous tissue removal is recommended. Mohs surgery shows promise.

    Conclusions:

    • DFSP, AFX, and CLS are soft tissue sarcomas with significant recurrence potential and occasional metastasis.
    • Adequate surgical margins are crucial for successful tumor removal.
    • Mohs micrographic surgery is increasingly recognized as a valuable technique for managing these difficult-to-treat neoplasms.