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Related Experiment Videos

Mechanisms underlying functional recovery following stroke

R G Lee1, P van Donkelaar

  • 1Department of Clinical Neurosciences, University of Calgary, Alberta, Canada.

The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques
|November 1, 1995
PubMed
Summary

Neuroplasticity allows the brain to reorganize functions after injury. Mechanisms like pathway unmasking and neural sprouting in the sensory and motor cortex may aid recovery after stroke.

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Area of Science:

  • Neuroscience
  • Neurobiology
  • Rehabilitation Science

Background:

  • The brain exhibits remarkable plasticity, allowing for functional reorganization.
  • Localized lesions or peripheral manipulations can induce changes in sensory and motor cortex representations.

Purpose of the Study:

  • To review evidence on neuroplasticity mechanisms following brain injury.
  • To explore the potential of neuroplasticity for functional recovery in humans, particularly after stroke.

Main Methods:

  • Review of animal experimental data on cortical reorganization.
  • Examination of studies utilizing positron emission tomography (PET) and transcranial magnetic stimulation (TMS) in humans.

Main Results:

  • Identified three key mechanisms of plastic reorganization: unmasking of inactive pathways, axonal sprouting and synaptogenesis, and CNS circuitry redundancy.

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  • Evidence suggests similar neuroplasticity occurs in the human brain, potentially contributing to post-stroke recovery.

    • Conclusions:

    • Neuroplasticity, involving mechanisms like unmasking and sprouting, is a significant factor in functional recovery.
    • Understanding these mechanisms offers potential therapeutic implications for stroke rehabilitation and other neurological conditions.