Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Does monozygotic twinning occur in mice?

A McLaren1, P Molland, E Signer

  • 1MRC Mammalian Development Unit, London.

Genetical Research
|December 1, 1995
PubMed
Summary

This study investigated monozygotic twinning in mice after induced ovulation. Researchers found no evidence of increased identical twins, suggesting they are rare or have low survival rates in mice.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Optimising same day discharge hemithyroidectomy: defining outcomes, unplanned admissions and patient experience.

Annals of the Royal College of Surgeons of England·2025
Same author

Development of a novel Bluetooth Low Energy device for proximity and location monitoring in grazing sheep.

Animal : an international journal of animal bioscience·2024
Same author

Genome-wide association studies of parasite resistance, productivity and immunology traits in Scottish Blackface sheep.

Animal : an international journal of animal bioscience·2024
Same author

Thyroid lobectomy for low-risk thyroid cancers.

Annals of the Royal College of Surgeons of England·2022
Same author

Metastatic seminoma with isolated gastric metastases: a case report.

Scottish medical journal·2019
Same author

New mastitis phenotypes suitable for genomic selection in meat sheep and their genetic relationships with udder conformation and lamb live weights.

Animal : an international journal of animal bioscience·2018

Area of Science:

  • Reproductive biology
  • Developmental genetics
  • Mammalian reproduction

Background:

  • Hormonally induced ovulation in humans is linked to increased monozygotic twinning.
  • Previous studies suggest monozygotic twinning may occur in mice.
  • The developmental basis for twinning after ovulation induction requires further investigation.

Purpose of the Study:

  • To compare monozygotic twinning rates in mice following spontaneous versus hormonally induced ovulation.
  • To analyze the developmental origins of twinning.
  • To establish a mouse model for studying twinning incidence.

Main Methods:

  • Phenotypic similarity within litters was used to identify potential twin pairs.
  • DNA fingerprinting with human minisatellite probes was employed for verification.
  • Over 2000 mice were observed, with 35 identified pairs analyzed.

Main Results:

  • No confirmed cases of monozygotic twins were identified among the 35 analyzed pairs.
  • All tested pairs originated from separate zygotes.
  • The study found no increase in monozygotic twinning after ovulation induction.

Conclusions:

  • Monozygotic twinning appears to be extremely rare in the studied mouse stock.
  • Alternatively, monozygotic twins may have significantly reduced viability, impacting survival to weaning.
  • Further research is needed to fully understand twinning mechanisms in mice.

Related Experiment Videos