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Related Experiment Videos

Degradation potential of plasma-sprayed hydroxyapatite-coated titanium implants

E P Paschalis1, Q Zhao, B E Tucker

  • 1Department of Chemistry, State University of New York at Buffalo 14214, USA.

Journal of Biomedical Materials Research
|December 1, 1995
PubMed
Summary

Dissolution rates of hydroxyapatite (HAP) coatings vary significantly between manufacturers, even when chemical composition and crystallinity remain unchanged. This highlights differences in how HAP coatings behave in aqueous environments.

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Area of Science:

  • Biomaterials Science
  • Materials Chemistry
  • Orthopedic Research

Background:

  • Hydroxyapatite (HAP) coatings are widely used in orthopedic devices for enhanced osseointegration.
  • Understanding the dissolution behavior of HAP coatings is crucial for predicting their long-term performance and biocompatibility.
  • Variability in HAP coating properties can influence their interaction with physiological environments.

Purpose of the Study:

  • To develop and apply an analytical method for assessing the dissolution characteristics of plasma-sprayed hydroxyapatite (HAP) coatings.
  • To compare the dissolution behavior of commercially available HAP coatings used in orthopedic applications.

Main Methods:

  • Preconditioning of HAP-coated titanium implants in a 0.15 mol L-1 sodium chloride solution at 37°C.

Related Experiment Videos

  • Dissolution testing using the dual constant composition (DCC) method under controlled undersaturation.
  • Analysis of coating crystallinity and composition using X-ray diffraction (XRD) and Fourier-transform infrared spectroscopy (FTIR).

    • Main Results:

    • Significant differences in dissolution rates, up to a factor of 5, were observed among various commercial HAP coatings.
    • No changes in crystallinity or chemical composition of the HAP coatings were detected before and after dissolution treatment via XRD and FTIR.
    • The aqueous environment elicited distinct dissolution responses from HAP coatings sourced from different manufacturers.

    Conclusions:

    • Plasma-sprayed HAP coatings from different commercial sources exhibit markedly different dissolution behaviors in aqueous environments.
    • Despite similar bulk properties (crystallinity, composition), extrinsic factors influence HAP coating dissolution rates.
    • Further research is required to correlate these in vitro dissolution findings with in vivo performance in orthopedic implants.