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Extramedullary hematopoiesis in pilomatricomas
S Kaddu1, C Beham-Schmid, H P Soyer
1Department of Dermatology, University of Graz, Austria.
The American Journal of Dermatopathology
|April 1, 1995
Summary
Extramedullary hematopoiesis, the presence of bone marrow elements, was found in regressive pilomatricomas. This localized phenomenon in skin tumors is not linked to systemic blood disorders.
Area of Science:
- Dermatopathology
- Surgical Pathology
- Hematology
Background:
- Pilomatricomas are common benign skin neoplasms.
- Extramedullary hematopoiesis typically occurs in conditions of hematopoietic stress.
Purpose of the Study:
- To investigate the occurrence and characteristics of extramedullary hematopoiesis in pilomatricomas.
- To determine if extramedullary hematopoiesis in pilomatricomas is associated with systemic hematological disorders.
Main Methods:
- Histopathological examination of 120 pilomatricoma cases.
- Identification of bone marrow cellular elements within the neoplasms.
Main Results:
- Seven cases (5.8%) of pilomatricomas showed histopathologic evidence of extramedullary hematopoiesis.
- Hematopoietic infiltrates included myeloid and erythroid precursors, and megakaryocytes in two cases.
- Extramedullary hematopoiesis was a localized phenomenon within the pilomatricomas and not associated with systemic disease.
Conclusions:
- Extramedullary hematopoiesis is an occasional finding in regressive pilomatricomas.
- This finding appears to be a localized event within the neoplasm.
- The clinical significance of extramedullary hematopoiesis in pilomatricomas requires further investigation.