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Related Experiment Videos

Ocular tumoral calcinosis. A clinicopathologic study

F Ghanchi1, A Ramsay, S Coupland

  • 1Tennent Institute of Ophthalmology, Western Infirmary, Glasgow, Scotland.

Archives of Ophthalmology (Chicago, Ill. : 1960)
|March 1, 1996
PubMed
Summary

Tumoral calcinosis, a rare disorder causing ectopic calcification, presented with unique ophthalmic findings in a patient with hyperphosphatemia. Ocular manifestations included conjunctival nodules and angioid streaks, offering insights into this systemic condition.

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Area of Science:

  • Ophthalmology
  • Dermatology
  • Nephrology

Background:

  • Tumoral calcinosis is a rare systemic disorder characterized by ectopic calcification near joints.
  • Hyperphosphatemia is a common metabolic derangement associated with tumoral calcinosis.
  • Ophthalmic manifestations of tumoral calcinosis are not well-documented.

Observation:

  • This case report details the ophthalmic features in a 38-year-old Asian woman with tumoral calcinosis and hyperphosphatemia.
  • Observed ophthalmic findings included palpebral conjunctival calcific nodules, the white limbal girdle of Vogt, optic disc drusen, and angioid streaks.
  • Morphologic study of conjunctival nodules revealed hydroxyapatite crystal deposition within an extracellular matrix containing mucopolysaccharides.

Findings:

  • Conjunctival calcific nodules in tumoral calcinosis are composed of hydroxyapatite crystals.

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  • The white limbal girdle of Vogt, disc drusen, and angioid streaks can be associated ophthalmic findings.
  • Surgical excision of eyelid nodules in this case did not result in recurrence.

    • Implications:

    • This case expands the understanding of the diverse ophthalmic manifestations of tumoral calcinosis.
    • Recognizing these ocular signs may aid in earlier diagnosis and management of tumoral calcinosis.
    • Further research is warranted to elucidate the pathogenesis of ocular calcification in tumoral calcinosis.