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Influence of a non-ionic radiography contrast medium on the microcirculation
1Cardiac Out-Patient Centre, Dresden, University Hospital of Saarland, Germany.
Acta Radiologica (Stockholm, Sweden : 1987)
|March 1, 1996
Summary
Iopromide contrast media significantly reduced erythrocyte velocity in skin capillaries during coronary angiography. This microcirculation disturbance may explain adverse effects observed in patients undergoing the procedure.
Area of Science:
- Cardiovascular medicine
- Radiology
- Microcirculation research
Background:
- Contrast media are frequently used in diagnostic imaging.
- Adverse effects associated with contrast media can occur.
- Microcirculatory disturbances are a potential cause of these adverse effects.
Purpose of the Study:
- To investigate the effect of iopromide 370 (Ultravist) on cutaneous microcirculation.
- To determine if iopromide influences erythrocyte velocity in nailfold capillaries.
Main Methods:
- A prospective study involving 15 patients undergoing diagnostic coronary angiography.
- Administration of 20 ml iopromide 370 and 20 ml 0.9% NaCl via the subclavian artery.
- Continuous measurement of erythrocyte velocity in ipsilateral nailfold capillaries before, during, and up to 6 minutes after injection.
Main Results:
- A significant decrease in erythrocyte velocity by 51.3% (p<0.0001) was observed on average 30 seconds post-iopromide injection.
- Reduced erythrocyte velocity persisted for up to 120 seconds.
- 14 out of 15 patients exhibited this reaction, with three experiencing temporary cessation of capillary blood flow.
Conclusions:
- Iopromide administration can induce significant, temporary microcirculatory disturbances.
- These findings suggest that contrast media-induced microcirculatory changes may contribute to adverse effects during coronary angiography.
- The study provides a potential explanation for adverse reactions observed in patients.