Cytotoxic antibody in the serum of cattle with squamous cell carcinoma

Sera from two cattle with ocular squamous cell carcinomas were cytotoxic for two different cultures of cells derived from bovine ocular squamous cell carcinomas. Sera from normal cattle, and from one tumour-bearing animal, were not cytotoxic. Cytotoxicity could be demonstrated in vitro only in the presence of guinea-pig complement.