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Related Experiment Videos

Insecticide solvents: interference with insecticidal action

L B Brattsten, C F Wilkinson

    Science (New York, N.Y.)
    |June 10, 1977
    PubMed
    Summary
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    Common insecticide solvents significantly boost the metabolism of certain chemicals in southern army-worm larvae. These solvents also protect larvae from insecticide toxicity, raising concerns about potential human health risks.

    Area of Science:

    • Entomology
    • Toxicology
    • Biochemistry

    Background:

    • Insecticide formulations often contain commercial solvent mixtures.
    • These solvents can influence the metabolic pathways of insects.
    • Understanding solvent-insecticide interactions is crucial for risk assessment.

    Purpose of the Study:

    • To investigate the effect of common insecticide carrier solvents on the metabolism of p-chloro N-methylaniline in southern army-worm (Spodoptera eridania) larvae.
    • To determine if these solvents offer protection against carbaryl toxicity in vivo.
    • To explore potential solvent-insecticide interactions and toxicological implications.

    Main Methods:

    • Oral exposure of southern army-worm larvae to test solvents.
    • Measurement of microsomal N-demethylation of p-chloro N-methylaniline in midgut preparations.

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  • Assessment of carbaryl toxicity in larvae exposed to solvent mixtures.

    • Main Results:

    • Commercial solvent mixtures increased microsomal N-demethylation of p-chloro N-methylaniline by over threefold.
    • The same solvent mixtures demonstrated a protective effect against carbaryl's in vivo toxicity.
    • Significant alterations in insect metabolism and insecticide efficacy were observed.

    Conclusions:

    • Insecticide carrier solvents can significantly alter insect metabolism and reduce insecticide efficacy.
    • Potential toxicological hazards to humans from these solvents warrant further investigation.
    • Solvent-insecticide interactions in field applications require careful consideration.