Increased serum calcium levels induced by furosemide

Area of Science:

• Nephrology
• Endocrinology
• Pharmacology

Background:

• Furosemide is a loop diuretic commonly used for fluid management.
• The effect of furosemide on serum calcium levels is dose-dependent and not fully elucidated.

Purpose of the Study:

• To investigate the impact of low-dose oral furosemide on serum calcium levels.
• To explore the potential dose-response relationship of furosemide concerning serum calcium.

Main Methods:

• A study involving thirteen male patients treated with furosemide 40 mg orally daily for three weeks.
• Serum calcium levels were measured using atomic absorption before and after the treatment period.

Main Results:

• Consistent elevation of serum calcium levels was observed after three weeks of treatment with 40 mg daily furosemide.
• This suggests a potential hypercalcemic effect at lower furosemide dosages.

Conclusions:

• Low-dose oral furosemide (40 mg daily) appears to increase serum calcium levels.
• Higher daily oral doses (>60 mg) may lead to hypocalcemia due to increased urinary calcium excretion.